PT-141 10mg

10mg · Bremelanotide · Melanocortin Receptor Agonist

Bremelanotide (PT-141) is a synthetic cyclic heptapeptide analogue of alpha-melanocyte-stimulating hormone (α-MSH), with nanomolar affinity for melanocortin receptors MC1R, MC3R, and MC4R. Unlike linear MSH analogues, it retains conformational rigidity attributable to its lactam bridge, which contributes to receptor selectivity in in vitro binding assays. In preclinical murine and primate models, MC4R engagement has been associated with modulation of hypothalamic neural circuitry governing autonomic function. Research applications include receptor binding displacement assays, CNS peptide signalling pathway elucidation, and melanocortin cascade characterisation. Molecular formula: C₅₀H₆₈N₁₄O₁₀; molecular weight: 1,025.2 g/mol. Supplied as lyophilised powder, ≥98% purity by HPLC. For in vitro research use only — not for human or veterinary administration.